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KMID : 0614020060210010060
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Journal of Pharmaceutical Sciences (C.N.U.)
2006 Volume.21 No. 1 p.60 ~ p.65
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Formulation design and evaluation for dermal delivery system of Doxepin hydrochloride topical formulations
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Lee Eun-Mi
Kim Jeong-Soo
Kyong Kee-Yeol
Lee Gye-Won
Jee Ung-Kil
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Abstract
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Doxepin hydrochloride(Dox) is a dibenzoxepin-derivative tricyclic antidepressant and used topically for the short-term relief of moderately severe pruritus associated with atopy dermatitis. Dox topical emulsion(or liposome) formulations were evaluated with respect to their rheological properities, permeation through excised skin of hairless mouse and in vitro/in vivo accumulation in the skin. The apparent viscosity was increased according to the concentration of glycerin and decreased with an increase in the concentration of phosphatidylcholine(PC). The permeation rate of formulation increased with a high concentration of PC and showed no relationship with the change of formulations. Amount of accumulated drug in the excised skin of hairless mouse was decreased with a high concentration of glycerin, but increased according to PC concentration.
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KEYWORD
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Doxepin hydrochloride, atopy dermatitis, liposome, phosphatidylcholine(PC)
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